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pac1 receptor antagonists  (Tocris)


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    Tocris pac1 receptor antagonists
    Pac1 Receptor Antagonists, supplied by Tocris, used in various techniques. Bioz Stars score: 94/100, based on 13 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/pac1+receptor+antagonist/pm37775045-76-31-38?v=Tocris
    Average 94 stars, based on 13 article reviews
    pac1 receptor antagonists - by Bioz Stars, 2026-07
    94/100 stars

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    A model depicting mechanosensitive regulation of s-ENTD release in the bladder lamina propria. Distention of the bladder wall during bladder filling causes activation of PIEZO channels [ , ] and mechanosensitive afferent neurons [ , , ] ( 2 ) as well as release of ATP [ , , ] and of soluble ectonucleotidases (s-ENTDs) from the urothelium into the lamina propria. ATP is then degraded to ADP, AMP and adenosine (ADO) by membrane-bound and s-ENTDs [ , ] ( 3 ). ATP, ADP and ADO activate P2X, P2Y and adenosine (AR) receptors in various cell types in the LP and detrusor muscle. Simultaneously, activation of PIEZO channels, TTX-sensitive neurons and <t>PAC1</t> receptors in response to distention restrain the additional release of s-ENTDs ( 4 ) to avert the excessive degradation of ATP and preserve bioactive purines at effective concentrations at receptor sites. Controlled inhibition of s-ENTD release is likely mediated by substances (e.g., PACAP and other neuropeptides) that are released from sensory neurons and/or urothelium in response to distention during bladder filling. The release of s-ENTDs and consequent extracellular ATP metabolism in the lamina propria is under complex regulation (Figure created with BioRender.com).
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    A model depicting mechanosensitive regulation of s-ENTD release in the bladder lamina propria. Distention of the bladder wall during bladder filling causes activation of PIEZO channels [ , ] and mechanosensitive afferent neurons [ , , ] ( 2 ) as well as release of ATP [ , , ] and of soluble ectonucleotidases (s-ENTDs) from the urothelium into the lamina propria. ATP is then degraded to ADP, AMP and adenosine (ADO) by membrane-bound and s-ENTDs [ , ] ( 3 ). ATP, ADP and ADO activate P2X, P2Y and adenosine (AR) receptors in various cell types in the LP and detrusor muscle. Simultaneously, activation of PIEZO channels, TTX-sensitive neurons and <t>PAC1</t> receptors in response to distention restrain the additional release of s-ENTDs ( 4 ) to avert the excessive degradation of ATP and preserve bioactive purines at effective concentrations at receptor sites. Controlled inhibition of s-ENTD release is likely mediated by substances (e.g., PACAP and other neuropeptides) that are released from sensory neurons and/or urothelium in response to distention during bladder filling. The release of s-ENTDs and consequent extracellular ATP metabolism in the lamina propria is under complex regulation (Figure created with BioRender.com).
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    Image Search Results


    A model depicting mechanosensitive regulation of s-ENTD release in the bladder lamina propria. Distention of the bladder wall during bladder filling causes activation of PIEZO channels [ , ] and mechanosensitive afferent neurons [ , , ] ( 2 ) as well as release of ATP [ , , ] and of soluble ectonucleotidases (s-ENTDs) from the urothelium into the lamina propria. ATP is then degraded to ADP, AMP and adenosine (ADO) by membrane-bound and s-ENTDs [ , ] ( 3 ). ATP, ADP and ADO activate P2X, P2Y and adenosine (AR) receptors in various cell types in the LP and detrusor muscle. Simultaneously, activation of PIEZO channels, TTX-sensitive neurons and PAC1 receptors in response to distention restrain the additional release of s-ENTDs ( 4 ) to avert the excessive degradation of ATP and preserve bioactive purines at effective concentrations at receptor sites. Controlled inhibition of s-ENTD release is likely mediated by substances (e.g., PACAP and other neuropeptides) that are released from sensory neurons and/or urothelium in response to distention during bladder filling. The release of s-ENTDs and consequent extracellular ATP metabolism in the lamina propria is under complex regulation (Figure created with BioRender.com).

    Journal: International Journal of Molecular Sciences

    Article Title: Sensory Neurons, PIEZO Channels and PAC1 Receptors Regulate the Mechanosensitive Release of Soluble Ectonucleotidases in the Murine Urinary Bladder Lamina Propria

    doi: 10.3390/ijms24087322

    Figure Lengend Snippet: A model depicting mechanosensitive regulation of s-ENTD release in the bladder lamina propria. Distention of the bladder wall during bladder filling causes activation of PIEZO channels [ , ] and mechanosensitive afferent neurons [ , , ] ( 2 ) as well as release of ATP [ , , ] and of soluble ectonucleotidases (s-ENTDs) from the urothelium into the lamina propria. ATP is then degraded to ADP, AMP and adenosine (ADO) by membrane-bound and s-ENTDs [ , ] ( 3 ). ATP, ADP and ADO activate P2X, P2Y and adenosine (AR) receptors in various cell types in the LP and detrusor muscle. Simultaneously, activation of PIEZO channels, TTX-sensitive neurons and PAC1 receptors in response to distention restrain the additional release of s-ENTDs ( 4 ) to avert the excessive degradation of ATP and preserve bioactive purines at effective concentrations at receptor sites. Controlled inhibition of s-ENTD release is likely mediated by substances (e.g., PACAP and other neuropeptides) that are released from sensory neurons and/or urothelium in response to distention during bladder filling. The release of s-ENTDs and consequent extracellular ATP metabolism in the lamina propria is under complex regulation (Figure created with BioRender.com).

    Article Snippet: PACAP6-38 , PAC1 receptor antagonist , 0.3 , KBS , Tocris Biosciences.

    Techniques: Activation Assay, Membrane, Inhibition

    Activators and inhibitors of membrane receptors and channels used in this study.

    Journal: International Journal of Molecular Sciences

    Article Title: Sensory Neurons, PIEZO Channels and PAC1 Receptors Regulate the Mechanosensitive Release of Soluble Ectonucleotidases in the Murine Urinary Bladder Lamina Propria

    doi: 10.3390/ijms24087322

    Figure Lengend Snippet: Activators and inhibitors of membrane receptors and channels used in this study.

    Article Snippet: PACAP6-38 , PAC1 receptor antagonist , 0.3 , KBS , Tocris Biosciences.

    Techniques: Membrane, Concentration Assay